Professor Milan Macek Jr. MD, DSc leads the largest academic medical/molecular genetics institution in the Czech Republic – Department of Biology and Medical Genetics of Charles University Prague-2nd School of Medicine and Motol University Hospital and the National Coordination Centre for Rare Diseases (www.nkcvo.cz; NKCVO). He chairs the National Rare Disease Taskforce at the Ministry of Health and coordinates Orpha.net nationally. As NKCVO chairman, he ensured Czechia's top EU13 ranking in European Reference Networks for rare diseases since 2017. He is a past President of the European Society of Human Genetics (www.eshg.org; 2010-2011 ESHG) and serves as the ESHG liaison for European National Human Genetics Societies. Under his leadership, medical genetics became an official EU specialty in 2011. He collaborated with the Council of Europe on the Additional protocol on genetic testing for health purposes to the Oviedo convention (2019). Prof. Macek was a board member of the European Cystic Fibrosis Society (ECFS.eu; 2007-2014) and is on the European Cystic Fibrosis Registry board. Within the European Society of Human Reproduction and Embryology (www.eshre.eu; ESHRE), he was responsible for joint position statements of ESHG and ESHRE in reproductive genetics. Prof. Macek is the president of the Czech Society of Medical Genetics and Genomics (www.slg.cz) and was the chief government advisor of the CZ EU Council presidency, under which the EU Council recommendation on rare diseases was adopted in 2009. During the second CZ EU Council presidency in 2022, he facilitated implementation for the Call for Action for rare diseases (www.mzcr.cz/towards-a-new-european-policy-framework-building-the-future-together-for-rare-diseases/). His citation index is over 24,000x, and he has an H-index of 60.